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急迫：167cm 180斤 怎么破？
平易惊人
• 最后回复
陈玉杰
•
2016-10-24 15:31
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实在看不懂，谁来指教一下？
hty8686
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费力科思
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2016-04-14 01:33
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【肥胖者联盟， 请叫我英雄！】
lily
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shendeng
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2016-03-23 11:08
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肥胖指数
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相关基因
FTO
位点：RS1121980
位点：RS1421085
位点：RS17817449
位点：RS3751812
位点：RS9939609
ANKK1
位点：RS1800497
SH2B1
位点：RS4788102
BDNF-AS
位点：RS925946
Hinney A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. 2007
Hotta K, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. 2008
Renström F, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. 4923
Loos RJ, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. 2008
Wing MR, et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. 2009
Vimaleswaran KS, et al. Physical activity attenuates the body mass index-increasing influence of genetic variation in the FTO gene. 2009
Li S, et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. 2010
Shimaoka I, et al. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. 2010
Kilpeläinen TO, et al. Obesity-susceptibility loci have a limited influence on birth weight: a meta-analysis of up to 28,219 individuals. 2011
Mei H, et al. Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood. 2012
Stratigopoulos G, et al. Regulation of Fto/Ftm gene expression in mice and humans. 2008
Chang YC, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. 2008
Tan JT, et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. 2008
Willer CJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. 2009
Hindorff LA, et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. 2009
Li X, et al. Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study. 2009
Luan J, et al. A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data. 2009
Malzahn D, et al. Tests for candidate-gene interaction for longitudinal quantitative traits measured in a large cohort. 2009
Adeyemo A, et al. FTO genetic variation and association with obesity in West Africans and African Americans. 2010
Zhang G, et al. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. 2010
Li S, et al. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. 2010
Wing MR, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. 2011
Wheeler HE, et al. Genetics and genomics of human ageing. 2011
Corella D, et al. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. 2011
Ahmad S, et al. Gene × physical activity interactions in obesity: combined analysis of 111,421 individuals of European ancestry. 2013
Tran B, et al. Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility. 2014
Global Lipids Genetics Consortium, et al. Discovery and refinement of loci associated with lipid levels. 2013
Dina C, et al. Variation in FTO contributes to childhood obesity and severe adult obesity. 2007
Scuteri A, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 2007
Price RA, et al. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. 2008
Villalobos-Comparán M, et al. The FTO gene is associated with adulthood obesity in the Mexican population. 2008
Stutzmann F, et al. Common genetic variation near MC4R is associated with eating behaviour patterns in European populations. 2009
Cha SW, et al. Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. 2008
Meyre D, et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. 2009
Wing MR, et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. 2009
Attaoua R, et al. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. 2009
Wangensteen T, et al. FTO genotype and weight gain in obese and normal weight adults from a Norwegian population based cohort (the HUNT study). 2010
Bressler J, et al. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. 2010
Kivimäki M, et al. Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004. 2011
Hotta K, et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. 2011
Cai H, et al. Prevalence and determinants of metabolic syndrome among women in Chinese rural areas. 2012
Ohashi J, et al. FTO polymorphisms in oceanic populations. 2007
Hinney A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. 2007
Hotta K, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. 2008
Chang YC, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. 2008
Attaoua R, et al. FTO gene associates to metabolic syndrome in women with polycystic ovary syndrome. 2008
Tan JT, et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. 2008
Qi L, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. 2008
Willer CJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. 2009
Cauchi S, et al. Combined effects of MC4R and FTO common genetic variants on obesity in European general populations. 2009
Lindgren CM, et al. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. 2009
Talmud PJ, et al. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. 2010
Ragvin A, et al. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. 2010
Hinney A, et al. From monogenic to polygenic obesity: recent advances. 2010
Fawcett KA, et al. The genetics of obesity: FTO leads the way. 2010
Ho AJ, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. 2010
Scherag A, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. 2010
Zhang G, et al. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. 2010
Hotta K, et al. Polymorphisms in NRXN3, TFAP2B, MSRA, LYPLAL1, FTO and MC4R and their effect on visceral fat area in the Japanese population. 2010
Wing MR, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. 2011
Ewens KG, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. 2011
Nock NL, et al. FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans. 2011
Mangge H, et al. Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents. 2011
Schum J, et al. Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention. 2012
Wang H, et al. Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis. 2012
McCaffery JM, et al. Obesity susceptibility loci and dietary intake in the Look AHEAD Trial. 2012
Bressler J, et al. Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study. 2013
Albuquerque D, et al. Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children. 2013
Peters U, et al. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. 2013
Tanaka T, et al. Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake. 2013
Tran B, et al. Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility. 2014
Berndt SI, et al. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. 2013
Wheeler E, et al. Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity. 2013
Namjou B, et al. EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children. 2013
Roetker NS, et al. Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study. 2012
Wojciechowski P, et al. Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis. 2012
Marcadenti A, et al. Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension. 2013
Chuang YF, et al. FTO genotype and aging: pleiotropic longitudinal effects on adiposity, brain function, impulsivity and diet. 2015
Scuteri A, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 2007
Do R, et al. Genetic variants of FTO influence adiposity, insulin sensitivity, leptin levels, and resting metabolic rate in the Quebec Family Study. 2008
Villalobos-Comparán M, et al. The FTO gene is associated with adulthood obesity in the Mexican population. 2008
Cha SW, et al. Replication of genetic effects of FTO polymorphisms on BMI in a Korean population. 2008
Hubacek JA, et al. A common variant in the FTO gene is associated with body mass index in males and postmenopausal females but not in premenopausal females. Czech post-MONICA and 3PMFs studies. 1368
Wing MR, et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. 2009
Scott RA, et al. FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. 2010
Hubáček JA, et al. FTO variant, energy intake, physical activity and basal metabolic rate in Caucasians. The HAPIEE study. 2010
Wang K, et al. A genome-wide association study on obesity and obesity-related traits. 2011
Dlouhá D, et al. Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms. 2010
González JR, et al. FTO risk haplotype among early onset and severe obesity cases in a population of western Spain. 2012
Ohashi J, et al. FTO polymorphisms in oceanic populations. 2007
Price RA, et al. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. 2008
Stratigopoulos G, et al. Regulation of Fto/Ftm gene expression in mice and humans. 2008
Chang YC, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. 2008
Tan JT, et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. 2008
Qi L, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. 2008
Hubacek JA, et al. The FTO gene and obesity in a large Eastern European population sample: the HAPIEE study. 2008
Hennig BJ, et al. FTO gene variation and measures of body mass in an African population. 2009
Ragvin A, et al. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. 2010
Hubacek JA, et al. A FTO variant and risk of acute coronary syndrome. 2010
Fawcett KA, et al. The genetics of obesity: FTO leads the way. 2010
Ho AJ, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. 2010
Zhang G, et al. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. 2010
Bressler J, et al. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. 2010
Wing MR, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. 2011
Ewens KG, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. 2011
Nock NL, et al. FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans. 2011
Mangge H, et al. Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents. 2011
Hubacek JA, et al. The FTO gene polymorphism is associated with end-stage renal disease: two large independent case-control studies in a general population. 2012
Prakash J, et al. Association of FTO rs17817449 SNP with obesity and associated physiological parameters in a north Indian population. 2011
Hubacek JA, et al. Lack of an association between three tagging SNPs within the FTO gene and smoking behavior. 2012
Schum J, et al. Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention. 2012
Lombard Z, et al. Appetite regulation genes are associated with body mass index in black South African adolescents: a genetic association study. 2012
Bressler J, et al. Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study. 2013
Tran B, et al. Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility. 2014
Garcia-Closas M, et al. Genome-wide association studies identify four ER negative-specific breast cancer risk loci. 2013
Michailidou K, et al. Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 2013
Dlouha D, et al. Association between FTO 1st intron tagging variant and telomere length in middle aged females. 3PMFs study. 2012
Zlatohlavek L, et al. FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention. 2013
Wang L, et al. Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. 2013
Pohjalainen T, et al. The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers. 1998
Klein TA, et al. Genetically determined differences in learning from errors. 2007
Blum K, et al. Increased prevalence of the Taq I A1 allele of the dopamine receptor gene (DRD2) in obesity with comorbid substance use disorder: a preliminary report. 1996
Munafò MR, et al. Lack of association of DRD2 rs1800497 (Taq1A) polymorphism with smoking cessation in a nicotine replacement therapy randomized trial. 2009
David SP, et al. Bupropion efficacy for smoking cessation is influenced by the DRD2 Taq1A polymorphism: analysis of pooled data from two clinical trials. 2007
Spellicy CJ, et al. A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. 2014
Jiang X, et al. Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells. 2014
Söderqvist S, et al. Polymorphisms in the dopamine receptor 2 gene region influence improvements during working memory training in children and adolescents. 2014
McAllister TW, et al. Single nucleotide polymorphisms in ANKK1 and the dopamine D2 receptor gene affect cognitive outcome shortly after traumatic brain injury: a replication and extension study. 2008
Esposito-Smythers C, et al. Associations of the DRD2 TaqIA polymorphism with impulsivity and substance use: preliminary results from a clinical sample of adolescents. 2009
Doehring A, et al. Genetic variants altering dopamine D2 receptor expression or function modulate the risk of opiate addiction and the dosage requirements of methadone substitution. 2009
Lucht M, et al. Influence of DRD2 and ANKK1 genotypes on apomorphine-induced growth hormone (GH) response in alcohol-dependent patients. 2010
van Strien T, et al. Parental control and the dopamine D2 receptor gene (DRD2) interaction on emotional eating in adolescence. 2010
Doehring A, et al. Genetic diagnostics of functional variants of the human dopamine D2 receptor gene. 2009
Breitling LP, et al. Prospective association of dopamine-related polymorphisms with smoking cessation in general care. 2010
Miller DK, et al. Acute intravenous synaptamine complex variant KB220™
van der Zwaluw CS, et al. Risky alcohol use in adolescence: the role of genetics (DRD2, SLC6A4) and coping motives. 2011
Li Y, et al. Single nucleotide polymorphism genotyping and point mutation detection by ligation on microarrays. 2011
Stapleton JA, et al. Association between DRD2/ANKK1 Taq1A genotypes, depression and smoking cessation with nicotine replacement therapy. 2011
Fernàndez-Castillo N, et al. Association study between the DAT1, DBH and DRD2 genes and cocaine dependence in a Spanish sample. 2010
Chen D, et al. Association between polymorphisms of DRD2 and DRD4 and opioid dependence: evidence from the current studies. 2011
Verde Z, et al. 'Smoking genes': a genetic association study. 2011
Lim J, et al. Dopaminergic polymorphisms associated with time-on-task declines and fatigue in the Psychomotor Vigilance Test. 2012
Bakker PR, et al. Candidate gene-based association study of antipsychotic-induced movement disorders in long-stay psychiatric patients: a prospective study. 2012
Winkler JK, et al. TaqIA polymorphism in dopamine D2 receptor gene complicates weight maintenance in younger obese patients. 2012
Davis C, et al. Binge eating disorder and the dopamine D2 receptor: genotypes and sub-phenotypes. 2012
Neville MJ, et al. Identification and characterization of ANKK1: a novel kinase gene closely linked to DRD2 on chromosome band 11q23.1. 2004
Hawi Z, et al. Preferential transmission of paternal alleles at risk genes in attention-deficit/hyperactivity disorder. 2005
Hu J, et al. No evidence for a major role of polymorphisms during bupropion treatment. 2006
Parsons MJ, et al. A dopamine D2 receptor gene-related polymorphism is associated with schizophrenia in a Spanish population isolate. 2007
Ton TG, et al. Genetic polymorphisms in dopamine-related genes and smoking cessation in women: a prospective cohort study. 2007
Yacubian J, et al. Gene-gene interaction associated with neural reward sensitivity. 2007
Elovainio M, et al. Genetic variants in the DRD2 gene moderate the relationship between stressful life events and depressive symptoms in adults: cardiovascular risk in young Finns study. 2007
Keltikangas-Järvinen L, et al. Dopamine receptor D2 gene Taq1A (C32806T) polymorphism modifies the relationship between birth weight and educational attainment in adulthood: 21-year follow-up of the Cardiovascular Risk in Young Finns study. 2007
Zhang Y, et al. Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory. 2007
Sand PG, et al. A lesson not learned: allele misassignment. 2007
Childs E, et al. Association between ADORA2A and DRD2 polymorphisms and caffeine-induced anxiety. 2008
Bombin I, et al. DRD3, but not COMT or DRD2, genotype affects executive functions in healthy and first-episode psychosis adolescents. 2008
Huang W, et al. Significant association of ANKK1 and detection of a functional polymorphism with nicotine dependence in an African-American sample. 2009
Prasad P, et al. Association of dopaminergic pathway gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetes. 2008
Perkins KA, et al. Gene and gene by sex associations with initial sensitivity to nicotine in nonsmokers. 2008
Shi J, et al. Genetic associations with schizophrenia: meta-analyses of 12 candidate genes. 2008
Thelma B, et al. Genetic underpinnings of tardive dyskinesia: passing the baton to pharmacogenetics. 2008
van der Zwaluw CS, et al. Interaction between dopamine D2 receptor genotype and parental rule-setting in adolescent alcohol use: evidence for a gene-parenting interaction. 2010
Boettiger CA, et al. Now or Later? An fMRI study of the effects of endogenous opioid blockade on a decision-making network. 2009
Hirvonen MM, et al. C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo. 2009
Saraswathy KN, et al. Haplotype diversity and linkage disequilibrium at DRD2 locus--a study on four population groups of Andhra Pradesh, India. 2009
Jocham G, et al. Dopamine DRD2 polymorphism alters reversal learning and associated neural activity. 2009
Englund A, et al. NPAS2 and PER2 are linked to risk factors of the metabolic syndrome. 2009
Ponce G, et al. The ANKK1 kinase gene and psychiatric disorders. 2009
Hou QF, et al. Potential association of DRD2 and DAT1 genetic variation with heroin dependence. 2009
Arbouw ME, et al. Clinical and pharmacogenetic determinants for the discontinuation of non-ergoline dopamine agonists in Parkinson's disease. 2009
Roe BE, et al. Financial and psychological risk attitudes associated with two single nucleotide polymorphisms in the nicotine receptor (CHRNA4) gene. 2009
Flegontova OV, et al. Haplotype frequencies at the DRD2 locus in populations of the East European Plain. 2009
Dubertret C, et al. A genetic schizophrenia-susceptibility region located between the ANKK1 and DRD2 genes. 2010
Prasad P, et al. Dopamine D2 receptor polymorphisms and susceptibility to alcohol dependence in Indian males: a preliminary study. 2010
Sjöholm LK, et al. CLOCK is suggested to associate with comorbid alcohol use and depressive disorders. 2010
Pinheiro AP, et al. The Genetics of Anorexia Nervosa: Current Findings and Future Perspectives. 2015
Ma J, et al. [DRD2/ANKK1 Taq IA polymorphism and early infant temperament]. 2010
Nemoda Z, et al. Association between dopaminergic polymorphisms and borderline personality traits among at-risk young adults and psychiatric inpatients. 2010
Sizoo B, et al. Do candidate genes discriminate patients with an autism spectrum disorder from those with attention deficit/hyperactivity disorder and is there an effect of lifetime substance use disorders? 2010
Lobo DS, et al. Association of functional variants in the dopamine D2-like receptors with risk for gambling behaviour in healthy Caucasian subjects. 2010
Bolton JL, et al. Association between polymorphisms of the dopamine receptor D2 and catechol-o-methyl transferase genes and cognitive function. 2010
Walter NT, et al. Interaction effect of functional variants of the BDNF and DRD2/ANKK1 gene is associated with alexithymia in healthy human subjects. 2011
Zhang JP, et al. Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction. 2011
Porcelli S, et al. Pharmacogenetics of antidepressant response. 2011
Koehler S, et al. Resting posterior minus frontal EEG slow oscillations is associated with extraversion and DRD2 genotype. 2011
McGuire V, et al. Association of DRD2 and DRD3 polymorphisms with Parkinson's disease in a multiethnic consortium. 2011
Wilcox CS, et al. ANKK1/DRD2 locus variants are associated with rimonabant efficacy in aiding smoking cessation: pilot data. 2011
Völter C, et al. Sensorimotor gating and D2 receptor signalling: evidence from a molecular genetic approach. 2012
Varga G, et al. Additive effects of serotonergic and dopaminergic polymorphisms on trait impulsivity. 2012
Voisey J, et al. A DRD2 and ANKK1 haplotype is associated with nicotine dependence. 2012
Nyman ES, et al. Sex-specific influence of DRD2 on ADHD-type temperament in a large population-based birth cohort. 2012
Swagell CD, et al. DRD2 C957T and TaqIA genotyping reveals gender effects and unique low-risk and high-risk genotypes in alcohol dependence. 2012
Olfson E, et al. Convergence of genome-wide association and candidate gene studies for alcoholism. 2012
Savitz J, et al. DRD2/ANKK1 Taq1A polymorphism (rs1800497) has opposing effects on D2/3 receptor binding in healthy controls and patients with major depressive disorder. 2013
Wong PC, et al. Linguistic grammar learning and DRD2-TAQ-IA polymorphism. 2013
Vereczkei A, et al. Multivariate analysis of dopaminergic gene variants as risk factors of heroin dependence. 2013
David SP, et al. Influence of a dopamine pathway additive genetic efficacy score on smoking cessation: results from two randomized clinical trials of bupropion. 2013
Roth CL, et al. Association analyses for dopamine receptor gene polymorphisms and weight status in a longitudinal analysis in obese children before and after lifestyle intervention. 2013
Bühler KM, et al. Risky alcohol consumption in young people is associated with the fatty acid amide hydrolase gene polymorphism C385A and affective rating of drug pictures. 2014
Spellicy CJ, et al. A variant in ANKK1 modulates acute subjective effects of cocaine: a preliminary study. 2014
Lin H, et al. Living in the moment: effects of time perspective and emotional valence of episodic thinking on delay discounting. 2014
Jiang X, et al. Single-nucleotide polymorphisms of the dopamine D2 receptor increase inflammation and fibrosis in human renal proximal tubule cells. 2014
Söderqvist S, et al. Polymorphisms in the dopamine receptor 2 gene region influence improvements during working memory training in children and adolescents. 2014
Thaler L, et al. Epistatic interactions implicating dopaminergic genes in bulimia nervosa (BN): relationships to eating- and personality-related psychopathology. 2012
Mignini F, et al. DRD2/ANKK1 TaqIA and SLC6A3 VNTR polymorphisms in alcohol dependence: association and gene-gene interaction study in a population of Central Italy. 2012
Wahlstrom LC, et al. DRD2/ANKK1 TaqI A genotype moderates the relationship between alexithymia and the relative value of alcohol among male college binge drinkers. 2012
Roetker NS, et al. Multigene interactions and the prediction of depression in the Wisconsin Longitudinal Study. 2012
Ghosh J, et al. Identification of a novel ANKK1 and other dopaminergic (DRD2 and DBH) gene variants in migraine susceptibility. 2013
McClure JB, et al. Pharmacogenetic smoking cessation intervention in a health care setting: a pilot feasibility study. 2013
Lawford BR, et al. DRD2/ANKK1 Taq1A (rs 1800497 C>T) genotypes are associated with susceptibility to second generation antipsychotic-induced akathisia. 2013
Spellicy CJ, et al. ANKK1 and DRD2 pharmacogenetics of disulfiram treatment for cocaine abuse. 2013
Ramos EM, et al. Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington's disease motor onset. 2013
Hirasawa-Fujita M, et al. Genetic Variation of the Mu Opioid Receptor (OPRM1) and Dopamine D2 Receptor (DRD2) is Related to Smoking Differences in Patients with Schizophrenia but not Bipolar Disorder. 2014
Zozulinsky P, et al. Dopamine system genes are associated with orienting bias among healthy individuals. 2014
Zhang C, et al. Identification of ANKK1 rs1800497 variant in schizophrenia: new data and meta-analysis. 2014
Yue JK, et al. Association of a common genetic variant within ANKK1 with six-month cognitive performance after traumatic brain injury. 2015
Pan YQ, et al. Association between ANKK1 (rs1800497) polymorphism of DRD2 gene and attention deficit hyperactivity disorder: a meta-analysis. 2015
Kang SG, et al. DRD2 genotypic and haplotype variation is associated with improvements in negative symptoms after 6 weeks' amisulpride treatment. 2015
Li H, et al. Association of LEPR and ANKK1 Gene Polymorphisms with Weight Gain in Epilepsy Patients Receiving Valproic Acid. 2015
Scuteri A, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 2007
Grant SF, et al. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. 2008
Wing MR, et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. 2009
Hassanein MT, et al. Fine mapping of the association with obesity at the FTO locus in African-derived populations. 2010
Okuda M, et al. Association between the FTO gene and overweight in Japanese children and adolescents. 2011
Hotta K, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. 2008
Qi L, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. 2008
Sabatti C, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 2009
Li M, et al. ATOM: a powerful gene-based association test by combining optimally weighted markers. 2009
Hennig BJ, et al. FTO gene variation and measures of body mass in an African population. 2009
Zhao J, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. 2009
Fawcett KA, et al. The genetics of obesity: FTO leads the way. 2010
Ho AJ, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. 2010
Zhang G, et al. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. 2010
Bressler J, et al. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. 2010
Zabaneh D, et al. A genome-wide association study of the metabolic syndrome in Indian Asian men. 2010
Wing MR, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. 2011
McCaffery JM, et al. FTO predicts weight regain in the Look AHEAD clinical trial. 2013
Cole JH, et al. Body mass index, but not FTO genotype or major depressive disorder, influences brain structure. 2013
Mitchell JA, et al. Obesity-susceptibility loci and the tails of the pediatric BMI distribution. 2013
Moore SC, et al. Common genetic variants and central adiposity among Asian-Indians. 2012
Wu J, et al. Association of FTO polymorphisms with obesity and metabolic parameters in Han Chinese adolescents. 2014
Thorleifsson G, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. 2009
Prudente S, et al. The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells. 2011
Jamshidi Y, et al. The SH2B gene is associated with serum leptin and body fat in normal female twins. 2007
Zhao J, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. 2009
Yang CW, et al. The joint effect of cigarette smoking and polymorphisms on LRP5, LEPR, near MC4R and SH2B1 genes on metabolic syndrome susceptibility in Taiwan. 2013
Xi B, et al. Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children. 2013
Prudente S, et al. The SH2B1 obesity locus and abnormal glucose homeostasis: lack of evidence for association from a meta-analysis in individuals of European ancestry. 2013
Zhao X, et al. An obesity genetic risk score is associated with metabolic syndrome in Chinese children. 2014
Xi B, et al. Sex-dependent associations of genetic variants identified by GWAS with indices of adiposity and obesity risk in a Chinese children population. 2013
Zhang M, et al. [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]. 2014
Thorleifsson G, et al. Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. 2009
Kocabas NA, et al. Brain-derived neurotrophic factor gene polymorphisms: influence on treatment response phenotypes of major depressive disorder. 2011
Hotta K, et al. Computed tomography analysis of the association between the SH2B1 rs7498665 single-nucleotide polymorphism and visceral fat area. 2011
Sandholt CH, et al. Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. 2011
Zhao J, et al. The role of obesity-associated loci identified in genome-wide association studies in the determination of pediatric BMI. 2009
Southam L, et al. Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? 2009
Cotsapas C, et al. Common body mass index-associated variants confer risk of extreme obesity. 2009
Elks CE, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. 2010
Morgan AR, et al. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. 2010
den Hoed M, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. 2010
Li S, et al. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. 2010
Robiou-du-Pont S, et al. Common variants near BDNF and SH2B1 show nominal evidence of association with snacking behavior in European populations. 2013
Kvaløy K, et al. Sex-specific effects of weight-affecting gene variants in a life course perspective--The HUNT Study, Norway. 2013
Frayling TM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. 2007
Wellcome Trust Case Control Consortium, et al. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. 2007
Hinney A, et al. Genome wide association (GWA) study for early onset extreme obesity supports the role of fat mass and obesity associated gene (FTO) variants. 2007
Hunt SC, et al. Association of the FTO gene with BMI. 2008
Li H, et al. Variants in the fat mass- and obesity-associated (FTO) gene are not associated with obesity in a Chinese Han population. 2008
Hertel JK, et al. Genetic analysis of recently identified type 2 diabetes loci in 1,638 unselected patients with type 2 diabetes and 1,858 control participants from a Norwegian population-based cohort (the HUNT study). 2008
Wardle J, et al. Obesity associated genetic variation in FTO is associated with diminished satiety. 2008
Hotta K, et al. Variations in the FTO gene are associated with severe obesity in the Japanese. 2008
Fisher E, et al. Association of the FTO rs9939609 single nucleotide polymorphism with C-reactive protein levels. 2009
Villalobos-Comparán M, et al. The FTO gene is associated with adulthood obesity in the Mexican population. 2008
Hakanen M, et al. FTO genotype is associated with body mass index after the age of seven years but not with energy intake or leisure-time physical activity. 2009
Zimmermann E, et al. Fatness-associated FTO gene variant increases mortality independent of fatness--in cohorts of Danish men. 2009
Song Y, et al. FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women. 2008
Frayling TM, et al. A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. 2007
Franks PW, et al. Assessing gene-treatment interactions at the FTO and INSIG2 loci on obesity-related traits in the Diabetes Prevention Program. 2008
Zabena C, et al. The FTO obesity gene. Genotyping and gene expression analysis in morbidly obese patients. 2009
Hennig BJ, et al. FTO gene variation and measures of body mass in an African population. 2009
Willer CJ, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. 2009
Cho YS, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. 2009
Wing MR, et al. Analysis of FTO gene variants with measures of obesity and glucose homeostasis in the IRAS Family Study. 2009
Grunnet LG, et al. Regulation and function of FTO mRNA expression in human skeletal muscle and subcutaneous adipose tissue. 2009
Grau K, et al. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans. 2009
Sonestedt E, et al. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. 2009
den Hoed M, et al. Postprandial responses in hunger and satiety are associated with the rs9939609 single nucleotide polymorphism in FTO. 2009
Tanofsky-Kraff M, et al. The FTO gene rs9939609 obesity-risk allele and loss of control over eating. 2009
Yan Q, et al. Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women. 2009
Doney AS, et al. The FTO gene is associated with an atherogenic lipid profile and myocardial infarction in patients with type 2 diabetes: a Genetics of Diabetes Audit and Research Study in Tayside Scotland (Go-DARTS) study. 2009
Karasawa S, et al. Association of the common fat mass and obesity associated (FTO) gene polymorphism with obesity in a Japanese population. 2010
Shimaoka I, et al. Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese. 2010
Rendo T, et al. Effects of the FTO gene on lifestyle intervention studies in children. 2009
Tan S, et al. Large effects on body mass index and insulin resistance of fat mass and obesity associated gene (FTO) variants in patients with polycystic ovary syndrome (PCOS). 2010
Hasselbalch AL, et al. A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. 2010
Li X, et al. A genetic variation in the fat mass- and obesity-associated gene is associated with obesity and newly diagnosed type 2 diabetes in a Chinese population. 2010
Xi B, et al. FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis. 2009
Liu G, et al. FTO variant rs9939609 is associated with body mass index and waist circumference, but not with energy intake or physical activity in European- and African-American youth. 2010
Lappalainen T, et al. Association of the FTO gene variant (rs9939609) with cardiovascular disease in men with abnormal glucose metabolism--the Finnish Diabetes Prevention Study. 2011
Gu HF, et al. The Common FTO Genetic Polymorphism rs9939609 is Associated with Increased BMI in Type 1 Diabetes but not with Diabetic Nephropathy. 2010
Bressler J, et al. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. 2010
Berulava T, et al. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. 2010
Mook-Kanamori DO, et al. No association of obesity gene FTO with body composition at the age of 6 months. The Generation R Study. 2011
Lee HJ, et al. Effects of common FTO gene variants associated with BMI on dietary intake and physical activity in Koreans. 2010
Kaakinen M, et al. Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. 1966
Mei H, et al. FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI. 2010
Fang H, et al. Variant rs9939609 in the FTO gene is associated with body mass index among Chinese children. 2010
Lappalainen T, et al. Gene expression of FTO in human subcutaneous adipose tissue, peripheral blood mononuclear cells and adipocyte cell line. 2010
Croteau-Chonka DC, et al. Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women. 2011
Sun Y, et al. Variants in the fat mass and obesity associated (FTO) gene are associated with obesity and C-reactive protein levels in Chinese Han populations. 2010
Corella D, et al. Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population. 2012
Zimmermann E, et al. Influences of the common FTO rs9939609 variant on inflammatory markers throughout a broad range of body mass index. 2011
Liu Y, et al. Meta-analysis added power to identify variants in FTO associated with type 2 diabetes and obesity in the Asian population. 2010
Elks CE, et al. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. 2010
Mangge H, et al. Rs9939609 variant of the fat mass and obesity-associated gene and trunk obesity in adolescents. 2011
Rutters F, et al. Associations between a single nucleotide polymorphism of the FTO Gene (rs9939609) and obesity-related characteristics over time during puberty in a Dutch children cohort. 2011
Okuda M, et al. Association between the FTO gene and overweight in Japanese children and adolescents. 2011
Jacobsson JA, et al. Detailed analysis of variants in FTO in association with body composition in a cohort of 70-year-olds suggests a weakened effect among elderly. 2011
Choh AC, et al. Differences in the heritability of growth and growth velocity during infancy and associations with FTO variants. 2011
Steemburgo T, et al. The rs7204609 polymorphism in the fat mass and obesity-associated gene is positively associated with central obesity and microalbuminuria in patients with type 2 diabetes from Southern Brazil. 2012
Hotta K, et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. 2011
Moleres A, et al. Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case-control study of children. 2012
Hunt SC, et al. Polymorphisms in the NPY2R gene show significant associations with BMI that are additive to FTO, MC4R, and NPFFR2 gene effects. 2011
Baturin AK, et al. [The study of polymorphism rs9939609 FTO gene in patients with overweight and obesity]. 2015
Zavattari P, et al. rs9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese children. 2011
Ramos RB, et al. Variations in the fat mass and obesity-associated (FTO) gene are related to glucose levels and higher lipid accumulation product in postmenopausal women from southern Brazil. 2011
Hallman DM, et al. The association of variants in the FTO gene with longitudinal body mass index profiles in non-Hispanic white children and adolescents. 2012
Mačeková S, et al. Association of the FTO rs9939609 polymorphism with obesity in Roma/Gypsy population. 2012
Abou-Hussein S, et al. Genetic factors in risk assessment for the development of type 2 diabetes mellitus in a small case series. 2015
González JR, et al. FTO risk haplotype among early onset and severe obesity cases in a population of western Spain. 2012
Klimentidis YC, et al. Associations of obesity genes with obesity-related outcomes in multiethnic children. 2011
Kilpeläinen TO, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. 2011
[PMID 22090522] PS2-41: The FTO Gene, Its Variants and Post-menopausal Breast Cancer
Klemetti M, et al. An obesity-related FTO variant and the risk of preeclampsia in a Finnish study population. 2011
Riffo B, et al. FTO gene is related to obesity in Chilean Amerindian children and impairs HOMA-IR in prepubertal girls. 2012
Povel CM, et al. Genetic variants and the metabolic syndrome: a systematic review. 2011
Lear SA, et al. Associations of the FTO rs9939609 variant with discrete body fat depots and dietary intake in a multi-ethnic cohort. 2011
Almén MS, et al. Genome wide analysis reveals association of a FTO gene variant with epigenetic changes. 2012
Prats-Puig A, et al. Variations in the obesity genes FTO, TMEM18 and NRXN3 influence the vulnerability of children to weight gain induced by short sleep duration. 2013
Vasan SK, et al. Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians. 2012
Vimaleswaran KS, et al. Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study. 2012
Wang J, et al. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. 2012
Luczynski W, et al. The association of the FTO rs9939609 polymorphism with obesity and metabolic risk factors for cardiovascular diseases in Polish children. 2012
Müller TD, et al. Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with bulimia nervosa and anorexia nervosa. 2012
Sentinelli F, et al. Association of FTO polymorphisms with early age of obesity in obese Italian subjects. 2012
Mei H, et al. Influences of FTO gene on onset age of adult overweight. 2012
Scuteri A, et al. Genome-wide association scan shows genetic variants in the FTO gene are associated with obesity-related traits. 2007
Ohashi J, et al. FTO polymorphisms in oceanic populations. 2007
Wåhlén K, et al. The common rs9939609 gene variant of the fat mass- and obesity-associated gene FTO is related to fat cell lipolysis. 2008
Omori S, et al. Association of CDKAL1, IGF2BP2, CDKN2A/B, HHEX, SLC30A8, and KCNJ11 with susceptibility to type 2 diabetes in a Japanese population. 2008
Price RA, et al. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs. 2008
Brockmöller J, et al. Pharmacogenetics: data, concepts and tools to improve drug discovery and drug treatment. 2008
Jacobsson JA, et al. Major gender difference in association of FTO gene variant among severely obese children with obesity and obesity related phenotypes. 2008
López-Bermejo A, et al. The association between the FTO gene and fat mass in humans develops by the postnatal age of two weeks. 2008
Stratigopoulos G, et al. Regulation of Fto/Ftm gene expression in mice and humans. 2008
Wilk JB, et al. NYD-SP18 is associated with obesity in the NHLBI Family Heart Study. 2008
Liu YJ, et al. Genome-wide association scans identified CTNNBL1 as a novel gene for obesity. 2008
Grant SF, et al. Association analysis of the FTO gene with obesity in children of Caucasian and African ancestry reveals a common tagging SNP. 2008
Al-Attar SA, et al. Association between the FTO rs9939609 polymorphism and the metabolic syndrome in a non-Caucasian multi-ethnic sample. 2008
Freathy RM, et al. Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI. 2008
Marvelle AF, et al. Association of FTO with obesity-related traits in the Cebu Longitudinal Health and Nutrition Survey (CLHNS) Cohort. 2008
Berentzen T, et al. Lack of association of fatness-related FTO gene variants with energy expenditure or physical activity. 2008
Loos RJ, et al. Common variants near MC4R are associated with fat mass, weight and risk of obesity. 2008
Ng MC, et al. Implication of genetic variants near TCF7L2, SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, and FTO in type 2 diabetes and obesity in 6,719 Asians. 2008
Barber TM, et al. Association of variants in the fat mass and obesity associated (FTO) gene with polycystic ovary syndrome. 2008
Chang YC, et al. Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population. 2008
Myles S, et al. Worldwide population differentiation at disease-associated SNPs. 2008
Kivimäki M, et al. Lifetime body mass index and later atherosclerosis risk in young adults: examining causal links using Mendelian randomization in the Cardiovascular Risk in Young Finns study. 2008
Sanghera DK, et al. Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk. 2008
Tan JT, et al. FTO variants are associated with obesity in the Chinese and Malay populations in Singapore. 2008
González-Sánchez JL, et al. Variant rs9939609 in the FTO gene is associated with obesity in an adult population from Spain. 2009
Qi L, et al. Fat mass-and obesity-associated (FTO) gene variant is associated with obesity: longitudinal analyses in two cohort studies and functional test. 2008
Jess T, et al. Impact on weight dynamics and general growth of the common FTO rs9939609: a longitudinal Danish cohort study. 2008
Andreasen CH, et al. Non-replication of genome-wide based associations between common variants in INSIG2 and PFKP and obesity in studies of 18,014 Danes. 2008
Kring SI, et al. FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness. 2008
Müller TD, et al. 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. 2008
Wardle J, et al. The FTO gene and measured food intake in children. 2009
Timpson NJ, et al. The fat mass- and obesity-associated locus and dietary intake in children. 2008
Mohlke KL, et al. Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants. 2008
Grunnet LG, et al. Increased recovery rates of phosphocreatine and inorganic phosphate after isometric contraction in oxidative muscle fibers and elevated hepatic insulin resistance in homozygous carriers of the A-allele of FTO rs9939609. 2009
Yajnik CS, et al. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. 2009
Rong R, et al. Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. 2009
Timpson NJ, et al. How does body fat influence bone mass in childhood? A Mendelian randomization approach. 2009
Cornes BK, et al. Replication of the association of common rs9939609 variant of FTO with increased BMI in an Australian adult twin population but no evidence for gene by environment (G x E) interaction. 2009
Timpson NJ, et al. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. 2009
Sabatti C, et al. Genome-wide association analysis of metabolic traits in a birth cohort from a founder population. 2009
Zobel DP, et al. Variants near MC4R are associated with obesity and influence obesity-related quantitative traits in a population of middle-aged people: studies of 14,940 Danes. 2009
Cecil JE, et al. An obesity-associated FTO gene variant and increased energy intake in children. 2008
Li M, et al. ATOM: a powerful gene-based association test by combining optimally weighted markers. 2009
Andreasen CH, et al. Lack of association between PKLR rs3020781 and NOS1AP rs7538490 and type 2 diabetes, overweight, obesity and related metabolic phenotypes in a Danish large-scale study: case-control studies and analyses of quantitative traits. 2008
Johnson AD, et al. An open access database of genome-wide association results. 2009
Lappalainen TJ, et al. The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study. 2009
Lowe JK, et al. Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. 2009
Reinehr T, et al. Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. 2009
Andreasen CH, et al. Studies of CTNNBL1 and FDFT1 variants and measures of obesity: analyses of quantitative traits and case-control studies in 18,014 Danes. 2009
Johnson L, et al. Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants. 2009
Deeb SS, et al. The role of the PGC1α Gly482Ser polymorphism in weight gain due to intensive diabetes therapy. 2009
Jonsson A, et al. Assessing the effect of interaction between an FTO variant (rs9939609) and physical activity on obesity in 15,925 Swedish and 2,511 Finnish adults. 2009
Legry V, et al. Effect of an FTO polymorphism on fat mass, obesity, and type 2 diabetes mellitus in the French MONICA Study. 2009
Raj SM, et al. No association of multiple type 2 diabetes loci with type 1 diabetes. 2009
Timpson NJ, et al. Does greater adiposity increase blood pressure and hypertension risk?: Mendelian randomization using the FTO/MC4R genotype. 2009
Hindorff LA, et al. Potential etiologic and functional implications of genome-wide association loci for human diseases and traits. 2009
Lappalainen S, et al. Genetic variation of FTO and TCF7L2 in premature adrenarche. 2009
Southam L, et al. Is the thrifty genotype hypothesis supported by evidence based on confirmed type 2 diabetes- and obesity-susceptibility variants? 2009
Cotsapas C, et al. Common body mass index-associated variants confer risk of extreme obesity. 2009
Heard-Costa NL, et al. NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium. 2009
Kowalska I, et al. The FTO gene modifies weight, fat mass and insulin sensitivity in women with polycystic ovary syndrome, where its role may be larger than in other phenotypes. 2009
Tabara Y, et al. Prognostic significance of FTO genotype in the development of obesity in Japanese: the J-SHIPP study. 2009
Crocker MK, et al. Pediatric obesity: etiology and treatment. 2009
Gallicchio L, et al. Single nucleotide polymorphisms in obesity-related genes and all-cause and cause-specific mortality: a prospective cohort study. 2009
Corpeleijn E, et al. Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: the NUGENOB study. 2010
Papathanasopoulos A, et al. A preliminary candidate genotype-intermediate phenotype study of satiation and gastric motor function in obesity. 2010
Hardy R, et al. Life course variations in the associations between FTO and MC4R gene variants and body size. 2010
He M, et al. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. 2010
Martinez-Gomez D, et al. Design and evaluation of a treatment programme for Spanish adolescents with overweight and obesity. The EVASYON Study. 2009
Wehr E, et al. Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome. 2010
Razquin C, et al. A 3-year intervention with a Mediterranean diet modified the association between the rs9939609 gene variant in FTO and body weight changes. 2010
Kerner B, et al. Use of longitudinal data in genetic studies in the genome-wide association studies era: summary of Group 14. 2009
Browning BL, et al. Simultaneous genotype calling and haplotype phasing improves genotype accuracy and reduces false-positive associations for genome-wide association studies. 2009
Jacobsson JA, et al. The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924. 2009
Kettunen J, et al. European lactase persistence genotype shows evidence of association with increase in body mass index. 2010
Li X, et al. Identifying association under a previous linkage peak on chromosome 16 for body mass index using cross-sectional and longitudinal data of the Framingham Heart Study. 2009
Fradin DD, et al. Influence of control selection in genome-wide association studies: the example of diabetes in the Framingham Heart Study. 2009
Luan J, et al. A multilevel linear mixed model of the association between candidate genes and weight and body mass index using the Framingham longitudinal family data. 2009
Parikh H, et al. Prioritizing genes for follow-up from genome wide association studies using information on gene expression in tissues relevant for type 2 diabetes mellitus. 2009
Ragvin A, et al. Long-range gene regulation links genomic type 2 diabetes and obesity risk regions to HHEX, SOX4, and IRX3. 2010
Hinney A, et al. From monogenic to polygenic obesity: recent advances. 2010
Lott L, et al. A genomics study of type 2 diabetes mellitus in U.S. Air Force personnel. 2009
Bassols J, et al. Placental FTO expression relates to fetal growth. 2010
Speakman JR, et al. FTO effect on energy demand versus food intake. 2010
Ruiz JR, et al. Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. 2010
Bollepalli S, et al. Association of FTO gene variants with adiposity in African-American adolescents. 2010
Fawcett KA, et al. The genetics of obesity: FTO leads the way. 2010
Ho AJ, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. 2010
Rutters F, et al. Genetic associations with acute stress-related changes in eating in the absence of hunger. 2010
Rodríguez-López R, et al. [Association of FTO gene polymorphisms and morbid obesity in the population of Extremadura (Spain)]. 2010
Zhang G, et al. Common SNPs in FTO gene are associated with obesity related anthropometric traits in an island population from the eastern Adriatic coast of Croatia. 2010
Han X, et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. 2010
Elks CE, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. 2010
Xi B, et al. The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. 2010
Bochud M, et al. Usefulness of Mendelian randomization in observational epidemiology. 2010
Morgan AR, et al. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. 2010
Timpson NJ, et al. C-reactive protein levels and body mass index: elucidating direction of causation through reciprocal Mendelian randomization. 2011
Rutters F, et al. Sleep duration and body-weight development during puberty in a Dutch children cohort. 2010
Orkunoglu-Suer FE, et al. MC4R variant is associated with BMI but not response to resistance training in young females. 2011
Li S, et al. Physical activity attenuates the genetic predisposition to obesity in 20,000 men and women from EPIC-Norfolk prospective population study. 2010
Labayen I, et al. Association between the FTO rs9939609 polymorphism and leptin in European adolescents: a possible link with energy balance control. The HELENA study. 2011
Huang W, et al. Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. 2011
Church C, et al. Overexpression of Fto leads to increased food intake and results in obesity. 2010
Keller L, et al. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. 2015
Wing MR, et al. Analysis of FTO gene variants with obesity and glucose homeostasis measures in the multiethnic Insulin Resistance Atherosclerosis Study cohort. 2011
Perez-Iglesias R, et al. Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment. 2010
Li M, et al. [Association of the rs9939609 polymorphism of FTO gene with overweight or obesity in Hazakh children]. 2010
Sonestedt E, et al. Association between fat intake, physical activity and mortality depending on genetic variation in FTO. 2011
Sobczyk-Kopciol A, et al. Inverse association of the obesity predisposing FTO rs9939609 genotype with alcohol consumption and risk for alcohol dependence. 2011
Lawlor DA, et al. Using genetic loci to understand the relationship between adiposity and psychological distress: a Mendelian Randomization study in the Copenhagen General Population Study of 53,221 adults. 2011
Ewens KG, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. 2011
Rees SD, et al. An FTO variant is associated with Type 2 diabetes in South Asian populations after accounting for body mass index and waist circumference. 2011
Nock NL, et al. FTO polymorphisms are associated with adult body mass index (BMI) and colorectal adenomas in African-Americans. 2011
Lurie G, et al. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. 2011
Sovio U, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. 2011
Hertel JK, et al. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. 2011
Benedict C, et al. The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men. 2011
Lawlor DA, et al. Maternal and offspring adiposity-related genetic variants and gestational weight gain. 2011
Demerath EW, et al. Interaction of FTO and physical activity level on adiposity in African-American and European-American adults: the ARIC study. 2011
Liou TH, et al. ESR1, FTO, and UCP2 genes interact with bariatric surgery affecting weight loss and glycemic control in severely obese patients. 2011
Matsuo T, et al. Effects of FTO genotype on weight loss and metabolic risk factors in response to calorie restriction among Japanese women. 2012
Corella D, et al. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. 2011
Li H, et al. Association of genetic variation in FTO with risk of obesity and type 2 diabetes with data from 96,551 East and South Asians. 2012
Tarabra E, et al. The obesity gene and colorectal cancer risk: a population study in Northern Italy. 2012
Delahanty LM, et al. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. 2012
Schum J, et al. Variants of the FTO gene in obese children and their impact on body composition and metabolism before and after lifestyle intervention. 2012
Wang H, et al. Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis. 2012
Lappalainen T, et al. Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study. 2012
Woehning A, et al. The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients. 2013
Zhou D, et al. Common variant (rs9939609) in the FTO gene is associated with metabolic syndrome. 2012
de Luis DA, et al. Effects of RS9939609 gene variant in FTO gene on weight loss and cardiovascular risk factors after biliopancreatic diversion surgery. 2012
Hotta K, et al. Association between type 2 diabetes genetic susceptibility loci and visceral and subcutaneous fat area as determined by computed tomography. 2012
Kowalska I, et al. Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome. 2012
Li G, et al. Association between FTO gene polymorphism and cancer risk: evidence from 16,277 cases and 31,153 controls. 2012
Phillips CM, et al. High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults. 2012
Thomsen M, et al. β2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals. 2012
Galbete C, et al. Lifestyle factors modify obesity risk linked to PPARG2 and FTO variants in an elderly population: a cross-sectional analysis in the SUN Project. 2013
Sällman Almén M, et al. Determination of the obesity-associated gene variants within the entire FTO gene by ultra-deep targeted sequencing in obese and lean children. 2013
Perry JR, et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. 2012
Warodomwichit D, et al. Causal inference of the effect of adiposity on bone mineral density in adults. 2013
Dwivedi OP, et al. Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children. 2012
Xi B, et al. The common SNP (rs9939609) in the FTO gene modifies the association between obesity and high blood pressure in Chinese children. 2013
Ortega-Azorín C, et al. Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. 2012
Ramos AV, et al. The contribution of FTO and UCP-1 SNPs to extreme obesity, diabetes and cardiovascular risk in Brazilian individuals. 2012
Bressler J, et al. Fat mass and obesity gene and cognitive decline: the Atherosclerosis Risk in Communities Study. 2013
de Luis DA, et al. The rs9939609 gene variant in FTO modified the metabolic response of weight loss after a 3-month intervention with a hypocaloric diet. 2013
Binh TQ, et al. Association of the common FTO-rs9939609 polymorphism with type 2 diabetes, independent of obesity-related traits in a Vietnamese population. 2013
Abarin T, et al. The impact of breastfeeding on FTO-related BMI growth trajectories: an application to the Raine pregnancy cohort study. 2012
Lauria F, et al. Prospective analysis of the association of a common variant of FTO (rs9939609) with adiposity in children: results of the IDEFICS study. 2012
de Luis DA, et al. [Relation of the rs9939609 gene variant in FTO with cardiovascular risk factor and serum adipokine levels in morbid obese patients]. 2012
Samaan Z, et al. The protective effect of the obesity-associated rs9939609 A variant in fat mass- and obesity-associated gene on depression. 2013
Albuquerque D, et al. Association of FTO polymorphisms with obesity and obesity-related outcomes in Portuguese children. 2013
Watanabe SY, et al. Association Study of Fat-mass and Obesity-associated Gene and Body Mass Index in Japanese Patients with Schizophrenia and Healthy Subjects. 2012
Vasan SK, et al. A common variant in the FTO locus is associated with waist-hip ratio in Indian adolescents. 2013
de Luis DA, et al. Relation of the rs9939609 gene variant in FTO with metabolic syndrome in obese female patients. 2013
Eynon N, et al. The FTO A/T polymorphism and elite athletic performance: a study involving three groups of European athletes. 2013
Fesinmeyer MD, et al. Effects of smoking on the genetic risk of obesity: the population architecture using genomics and epidemiology study. 2013
Ramos RB, et al. Fat mass and obesity-associated gene polymorphisms do not affect metabolic response to hormone therapy in healthy postmenopausal women. 2012
Li T, et al. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. 2013
Kalnina I, et al. Polymorphisms in FTO and near TMEM18 associate with type 2 diabetes and predispose to younger age at diagnosis of diabetes. 2013
Knüppel S, et al. Evaluation of 41 candidate gene variants for obesity in the EPIC-Potsdam cohort by multi-locus stepwise regression. 2013
Carlos FF, et al. Association of FTO and PPARG polymorphisms with obesity in Portuguese women. 2013
Xi B, et al. Study of 11 BMI-associated loci identified in GWAS for associations with central obesity in the Chinese children. 2013
Mägi R, et al. Contribution of 32 GWAS-identified common variants to severe obesity in European adults referred for bariatric surgery. 2013
Vasan SK, et al. FTO genetic variants and risk of obesity and type 2 diabetes: a meta-analysis of 28,394 Indians. 2014
Kong X, et al. Association of genetic variants with isolated fasting hyperglycaemia and isolated postprandial hyperglycaemia in a Han Chinese population. 2013
Tran B, et al. Association between fat-mass-and-obesity-associated (FTO) gene and hip fracture susceptibility. 2014
Burgdörfer E, et al. FTO and INSIG2 Genotyping Combined with Metabolic and Anthropometric Phenotyping of Morbidly Obese Patients. 2013
Zhao X, et al. An obesity genetic risk score is associated with metabolic syndrome in Chinese children. 2014
Olza J, et al. Influence of FTO variants on obesity, inflammation and cardiovascular disease risk biomarkers in Spanish children: a case-control multicentre study. 2013
Huang T, et al. FTO genotype, dietary protein, and change in appetite: the Preventing Overweight Using Novel Dietary Strategies trial. 2014
Gustavsson J, et al. FTO genotype, physical activity, and coronary heart disease risk in Swedish men and women. 2014
Wojciechowski P, et al. Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis. 2012
Pyrzak B, et al. Relation of fat-mass and obesity-associated gene polymorphism to fat mass content and body mass index in obese children. 2015
de Luis DA, et al. Evaluation of weight loss and adipocytokines levels after two hypocaloric diets with different macronutrient distribution in obese subjects with rs9939609 gene variant. 2012
McMurray F, et al. From mice to humans. 2012
Reynolds GP, et al. The obesity risk gene FTO influences body mass in chronic schizophrenia but not initial antipsychotic drug-induced weight gain in first-episode patients. 2013
Dougkas A, et al. The impact of obesity-related SNP on appetite and energy intake. 2013
Sull JW, et al. Replication of genetic effects of MC4R polymorphisms on body mass index in a Korean population. 2013
Dayeh TA, et al. Identification of CpG-SNPs associated with type 2 diabetes and differential DNA methylation in human pancreatic islets. 2013
Garver WS, et al. The genetics of childhood obesity and interaction with dietary macronutrients. 2013
Xi B, et al. Associations of obesity susceptibility loci with hypertension in Chinese children. 2013
Brunkwall L, et al. Genetic variation in the fat mass and obesity-associated gene (FTO) in association with food preferences in healthy adults. 2013
Wang L, et al. Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. 2013
Stender S, et al. Elevated body mass index as a causal risk factor for symptomatic gallstone disease: a Mendelian randomization study. 2013
Marcadenti A, et al. Effects of FTO RS9939906 and MC4R RS17782313 on obesity, type 2 diabetes mellitus and blood pressure in patients with hypertension. 2013
Rode L, et al. Increased body mass index, elevated C-reactive protein, and short telomere length. 2014
Reinehr T, et al. FTO gene: association to weight regain after lifestyle intervention in overweight children. 2014
Wu J, et al. Association of FTO polymorphisms with obesity and metabolic parameters in Han Chinese adolescents. 2014
Foraita R, et al. Does the FTO gene interact with the socioeconomic status on the obesity development among young European children? Results from the IDEFICS study. 2015
Klovaite J, et al. Obesity as a causal risk factor for deep venous thrombosis: a Mendelian randomization study. 2015
Łuczyński W, et al. Disease associated clinical factors and FTO polymorphism: effect on body mass in children with type 1 diabetes mellitus. 2014
Luczyński W, et al. Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity. 2014
Zhang M, et al. [Impact of obesity-related gene polymorphism on risk of obesity and metabolic disorder in childhood]. 2014
Qi Q, et al. Dietary Intake, FTO Genetic Variants, and Adiposity: A Combined Analysis of Over 16,000 Children and Adolescents. 2015
Bandstein M, et al. The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients. 2015
Zimmermann E, et al. Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults. 2015
Fawwad A, et al. Common variant within the FTO gene, rs9939609, obesity and type 2 diabetes in population of Karachi, Pakistan. 2015
Bernacka-Wojcik I, et al. Single nucleotide polymorphism detection using gold nanoprobes and bio-microfluidic platform with embedded microlenses. 2015
Balasar Ö, et al. The effect of rs9939609 FTO gene polymorphism on weight loss after laparoscopic sleeve gastrectomy. 2015
Muc M, et al. Influence of physical activity on the association between the FTO variant rs9939609 and adiposity in young adults. 2015
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